Specialized pro-resolving mediators (SPMs) are biosynthesized from omega-3 fatty acids and used by our bodies to help resolve inflammation. If inflammation isn't resolved it can result in fibrosis, scarring, impaired cellular function, degeneration, and hypersensitivity (increased pain sensation). How do they help resolve inflammation you ask?
SPMs stimulate living cells called phagocytes to ingest macrophages, which are cells that present antigens to T cells and initiate inflammation. Ingesting the macrophages enables the inflammation to be kept within the boundaries of the injury resulting in the clearance of pain.
According to a study conducted at Lazarus Wellness in 2019, SPMs taken every day for 8 weeks led to improvements in mood, mental clarity, stress, and fatigue, as well as reduction in bodily discomfort after a typical workout.
Posted In: Nutrition